Comparative toxicity of chloroguanide and nitroguanil
Identifieur interne : 003C66 ( Main/Exploration ); précédent : 003C65; suivant : 003C67Comparative toxicity of chloroguanide and nitroguanil
Auteurs : Domingo M. Aviado [États-Unis] ; Tsutomu Inoh [États-Unis] ; Young W. Cho [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1968.
English descriptors
- Teeft :
- Acute toxicity, Aminami aromatyczymi, Antimalarial, Antimalarial activity, Aortic, Aortic blood pressure, Aromatic amines, Atria1, Atria1 contraction, Atria1 muscle, Aviado, Berghei, Blood pressure, Body weight, Cardiac, Cardiac effects, Cardiac output, Chloroguanide, Control chloroguanide, Control nitroguanil, Derivative, Dmso, Dos, Drug administration, Drug injection, Femoral artery, First group, Gastric, Gastric acidity, Gastric juice, Gastric secretion, Histamine, Intestinal motility, Intravenous injections, Malarial parasite, Mouse, Mouse mouse, Nictitating membrane, Nitroguanil, Normal malaria nitroguanil, Normal nitroguanil, Optical density, Parasitemia, Pathologic physiology, Petechial hemorrhages, Plasmodium, Plasmodium berghei, Present address, Pulmonary artery, Pulmonary resistance, Respiratory enzymes, Same dose, Statham transducer, Systemic blood pressure, Tidal volume, Toxicity, Tsutomu inoh, Untreated controls, Urbanski.
Abstract
Abstract: The pharmacologic actions of these two antimalarial drugs were compared in mice, rats, cats, and dogs. The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. Both drugs suppressed the parasitemia and prolonged the survival of the rat and mouse infected with Plasmodium berghei.
Url:
DOI: 10.1016/0041-008X(68)90097-5
Affiliations:
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Cho</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1968">1968</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="228">228</biblScope><biblScope unit="page" to="241">241</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute toxicity</term><term>Aminami aromatyczymi</term><term>Antimalarial</term><term>Antimalarial activity</term><term>Aortic</term><term>Aortic blood pressure</term><term>Aromatic amines</term><term>Atria1</term><term>Atria1 contraction</term><term>Atria1 muscle</term><term>Aviado</term><term>Berghei</term><term>Blood pressure</term><term>Body weight</term><term>Cardiac</term><term>Cardiac effects</term><term>Cardiac output</term><term>Chloroguanide</term><term>Control chloroguanide</term><term>Control nitroguanil</term><term>Derivative</term><term>Dmso</term><term>Dos</term><term>Drug administration</term><term>Drug injection</term><term>Femoral artery</term><term>First group</term><term>Gastric</term><term>Gastric acidity</term><term>Gastric juice</term><term>Gastric secretion</term><term>Histamine</term><term>Intestinal motility</term><term>Intravenous injections</term><term>Malarial parasite</term><term>Mouse</term><term>Mouse mouse</term><term>Nictitating membrane</term><term>Nitroguanil</term><term>Normal malaria nitroguanil</term><term>Normal nitroguanil</term><term>Optical density</term><term>Parasitemia</term><term>Pathologic physiology</term><term>Petechial hemorrhages</term><term>Plasmodium</term><term>Plasmodium berghei</term><term>Present address</term><term>Pulmonary artery</term><term>Pulmonary resistance</term><term>Respiratory enzymes</term><term>Same dose</term><term>Statham transducer</term><term>Systemic blood pressure</term><term>Tidal volume</term><term>Toxicity</term><term>Tsutomu inoh</term><term>Untreated controls</term><term>Urbanski</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The pharmacologic actions of these two antimalarial drugs were compared in mice, rats, cats, and dogs. The cardiac effects of both chloroguanide and nitroguanil include depression of excitability of rat atrial muscle, depression of respiratory enzymes of mouse heart homogenate, and depression of myocardial contractility of cat heart. The dog showed an elevation in cardiac output following nitroguanil, but no change following chloroguanide. The decrease in fertility and reduction of body weight induced by chronic administration of nitroguanil in the mouse were less severe than those of chloroguanide. In the cat, chloroguanide but not nitroguanil, reduced gastric secretion. Both drugs suppressed the parasitemia and prolonged the survival of the rat and mouse infected with Plasmodium berghei.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name></region><name sortKey="Cho, Young W" sort="Cho, Young W" uniqKey="Cho Y" first="Young W." last="Cho">Young W. Cho</name><name sortKey="Inoh, Tsutomu" sort="Inoh, Tsutomu" uniqKey="Inoh T" first="Tsutomu" last="Inoh">Tsutomu Inoh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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